Job Description

ROLE SUMMARY

The Internal Medicine Research Unit (IMRU) is seeking a highly motivated laboratory scientist to be a member of the in vitro pharmacology/assay development group. This Senior Associate Scientist will be an integral member of a team which broadly supports the IMRU portfolio across all the disease areas of interest. The individual will apply a scientific background in in vitro pharmacology to develop primary assays for carrying out SAR (structure-activity relationships) and design/execute experiments for understanding the mechanism of action of compounds throughout different stages of the project. In this position, the successful candidate will work within a large matrix environment, across a portfolio of programs, collaborating with multiple groups including discovery biology and several partner lines including medicinal chemistry and the central primary pharmacology group.

ROLE RESPONSIBILITIES

* Perform laboratory experiments to establish robust biochemical and cell-based compound screening assays across a broad array of target classes for metabolism project teams.
* Maintain immortalized cell, primary cell and iPS cell cultures as needed for assay development and low volume screening efforts.
* Collaborate with the Primary Pharmacology Group to ensure alignment around assay technology selection, assay quality criteria and validation requirements.
* Operate a broad array of liquid-handling and plate-based pharmacology equipment to ensure efficient automated workflows for newly developed assays.
* Ensure efficient assay transfer to Primary Pharmacology Group or external screening vendors.
* Prepare and present experimental results to project teams.
* Maintain high quality experimental records within electronic laboratory notebook.

QUALIFICATIONS

* BA, BS or Masters in biology, pharmacology, biochemistry or a related field with 3 years of laboratory experience relevant to this position.
* Broad understanding of biology, preferably with an emphasis in neuroscience and/or metabolism.
* Scientific understanding of the major target classes (GPCRs, enzymes, transporters, ion channels, etc.).
* Experience with assay development methodologies.
* Experience with cell culture (primary and immortalized).
* Experience in low to moderate throughput compound screening preferred but not mandatory.
* Experience with automation of liquid handling and screening workflows preferred but not mandatory.
* Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, or equivalent software.
* Ability to complete experiments and present results in individual and group settings.
* Ability to work on multiple programs simultaneously and be an integral member of cross-functional project teams.
* Proven verbal and written communication skills, and the ability to work in a collaborative team environment.

Other Job Details:

* Last Date to Apply for Job: February 22, 2021
* Eligible for Employee Referral Bonus: YES

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Research and Development

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