Job Description

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

In the plan to create a new hub for mRNA-based vaccine discovery in Cambridge, we are building new laboratories that will be focused on the development of state-of-the-art methods that will be supporting deep product understanding, process and product development, as well as testing of pre-clinical and clinical samples for new mRNA-based vaccines.

The Scientist in the In Vivo Immunology team will support preclinical in vivo studies and will represent the project team in spearheading GSK’s innovation of novel viral vaccines and platform programs. You will have the opportunity to support the in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners in a collaborative and matrix team. You will help design and write in vivo study protocols, coordinate and initiate preclinical studies, conduct experiments and analyze experimental data pertaining to the understanding of cellular mediated immune responses and humoral immune responses from novel vaccine candidates, formulations, and platforms.

Key Responsibilities:

This role will provide you with the opportunity to lead key activities and to progress your career based on performance. The responsibilities include the following:

As a preclinical in vivo study lead, you will work in a matrix team to support the identification of novel vaccine candidates and support platform development.
Help design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs.
Prior vivarium management experience is desired to help assist with vivarium operations and setup.
Schedule, manage and track the life cycle of in vivo studies.
Conduct dosing, IVIS imaging, necropsy, and tissue harvest from animal studies
Train and assess new employees’ animal handling, dosing, sample collection, and surgical procedures
Implement and ensure adherence to GSK and regulatory requirements for compliance with IACUC guidelines through writing and reviewing in vivo study protocols and participating in the Independent Scientific Review committee.
Perform experiments characterizing immune response for preclinical immunogenicity or challenge studies using flow cytometry and other immune assays.
Analyze experimental date and document them in detail using an electronic notebook
Prepare and document study protocols and final reports for projects as an author.
Contribute to patent filing, IND submissions, and scientific publications.
Present study plans and results at project meetings.
Develop new experimental techniques based on project needs.

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

Ph.D., M.S., or B.S. degree in immunology or a related field. The required post-graduate work experience is 0 or more years for a Ph.D., 2+ years for an M.S., and 5+ years for a B.S.
Two or more years of experience in conducting in vivo animal studies within the fields of vaccines, infectious diseases, or immunology.
Two or more years of experience in small rodent handling and drug administration, in-study blood sampling, tissue harvest, and processing.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

A collaborative team player with strong interpersonal skills to work with diverse groups within the organization.

Detail-oriented with the agility to balance multiple projects.

Extremely organized with experience in documentation of study protocols and reports.

Experience with immune-response related readout methods such as ELISA, Flow, Luminex, or qPCR methodologies.
Excellent communication and writing skills.
Deep understanding of immunology

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