Job Description

Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Principal Scientist MOA Discovery on our Early Target Discovery Team located at our San Diego, California office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

OBJECTIVES/PURPOSE

The Principal Scientist of Variant Function Discovery, based in San Diego, leads mechanism of discovery projects that employ innovative technologies for functional characterization of human genetic variants that cause rare diseases or protect from pathogenic phenotypes  (e.g., biochemical & cell based assays, modifier allele assays, enzyme assays, etc).  The Principal Scientist coordinates the Early Target Discovery’s disease associated variants characterization efforts in rare diseases aligned with Takeda’s related Drug Discovery Units. This individual works collaboratively and effectively with internal and external resources in validating targets to build persuasive cases supporting the initiation of drug discovery programs by Takeda Research.

ACCOUNTABILITIES

Coordinates the Early Target Discovery’s monogenic disease variant characterization and modifier discovery efforts in broad rare diseases.
Serves as project leader to characterize MOA in general
Identifies opportunities to collaborate with partners (academic, biotech, and CRO) to enhance in-house capabilities. Leads and manages external collaborations effectively
Oversees effective and productive execution of collaborations, consortiums, and other external relationships relating to rare disease genotype-phenotype associations.
Represents own and group research findings to leadership and project teams.
Experimental hands-on experience in some of the following is highly desirable: drug discovery experience, in vitro and molecular pharmacology, functional characterization of novel huamn genetic variants (e.g., amino acid substitutions, truncations, etc.).
Has demonstrated independent thought/creativity in proteins that cause genetic disorders in general and technical proficiency in novel protein variant characterization methodologies

Leadership

Scientific leadership role, setting high standards for effectiveness of execution, and rigor of thought
Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
Track record of working on complex problems, and ability to integrate data from multiple disciplines

Decision-making and Autonomy

Independently manages workload and expectations
Scientific driver for research strategy that impacts group internally and outside area of function

Interaction

Initiates and leads external interactions and collaborations
Frequent contact with internal and external personnel at various management levels

Innovation

Determines methods on new assignments; makes strategic recommendations on projects
Ability to provide novel creative solutions to challenging problems

EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:

PhD degree in a scientific discipline with 6+ years experience , or
MS with 10+ years experience, or
BS with 12+ years experience
4 or more years of Industry experience required
4 years of managerial experience required

WHAT TAKEDA CAN OFFER YOU:

401(k) with company match and Annual Retirement Contribution Plan
Tuition reimbursement
Company match of charitable contributions
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs