Job Description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science. In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The successful candidate will play a key role in the downstream purification function within the Discovery Protein Science group, supporting a wide range of therapeutic programs. Responsibilities will be focused on biologic drug candidate developability including platform suitability and non-platform process development. Additional responsibilities will include drug candidate generation spanning multiple modalities as well as reagent generation in support of early stage Discovery programs.

* Support downstream purification efforts (reagents & therapeutics), with a focus on process design, implementation, optimization and troubleshooting. Develop scaleable, phase appropriate purification processes for non-platform drug candidates.
* Perform platform suitability and manufacturability assessments as part of enabling package for therapeutic candidates transitioning to the manufacturing development organization.
* Protein production for mid-stage Discovery programs to support cyno tox studies, concentratability, PK/PD, formulation/analytical development etc.
* Perform mid-scale purifications for the evaluation and comparison of early Discovery therapeutic candidates.
* Deliver on reagent requests to support Discovery programs.
* Troubleshoot downstream purification processes and chromatography instrumentation.
* Support upstream mammalian and bacterial expression efforts.
* Contribute to the continuous improvement effort for the Discovery manufacturability assessment in collaboration with Manufacturing Development.
* Participate in the preparation of technical reports, summaries, protocols, and regulatory documents, where necessary.

MAJOR SKILLS REQUIRED:

* B.S. in a scientific discipline and at least 5 years of relevant laboratory experience or M.S. with at least 3 years of relevant experience preferred.
* Protein purification experience including method development, optimization, and the ability to troubleshoot standard purification protocols and instrumentation.
* Experience with larger scale protein production (CMC, and tech transfer experience is a plus).
* Hands on experience in the operation and control of chromatography workstations (AKTA, BioRad, etc.).
* Excellent technical, organizational, and analytical skills are required.
* Protein characterization experience (biophysical, spectroscopy, protein assays, SDS-PAGE)
* Experience with LIMS and Electronic Notebook is a plus.
* Excellent communication skills, evidence of innovative thinking, and ability to work with a sense of urgency under tight deadlines.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.