Job Description

Job Description

The Exploratory Science Center (MESC) Cambridge, a wholly-owned subsidiary, is focused on driving early discovery research. Co-located with our company's Cambridge Innovation Hub, the ESCs disease-area-agnostic research agenda fosters hands-on collaboration between our scientists and external academic and biotech researchers to access and explore the most promising emerging science.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create a fast-paced, nimble and flexible environment of mutual respect, creativity, invention and teamwork. With access to our company's proven global R&D organization, youll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

We are seeking an innovative protein biochemist or bioconjugation chemist to join the Exploratory Science Center (MESC) in Cambridge, MA.

The successful candidate will become part of a lab-based, creative and fast-paced team that will discover novel biology and invent impactful technologies targeting oncology, inflammation, cardiovascular, metabolism and neuroscience.

This is a lab-based position and an excellent opportunity for someone seeking scientific and career growth in a multidisciplinary area of drug discovery. Your personal growth and career development will contribute to the success of our team.

Responsibilities include and are not limited to the following:

* Cloning, expression, and purification of proteins including antigens, immunoglobulins, antibody fragments and other modalities
* Multi-step protein purification including tag-less purification
* Develop bio-conjugation technologies and optimize, purify bio-conjugates for in vitro and in vivo evaluation
* Functional and biophysical characterization of proteins and bio-conjugates
* Leverage advances in synthesis and delivery technologies of complex large molecules to impact multiple ESC programs
* Help identify and validate new targets, which may include collaborative engagement with the external scientific community and leadership of early drug discovery projects
* Act as a leader from the bench, driving program, strategy and execution
* The candidate will be part of a cross-functional team contributing to the strategic direction of research programs across multiple therapeutic modalities
* Provide scientific mentoring and technical training of team members as appropriate

Qualifications

Education:

* PhD in protein biochemistry, chemical biology, macromolecular chemistry or related discipline
* Minimum of 0 to 3 experience after PhD

Required Experience:

* Strong background in protein purification, protein chemistry and conjugation with small molecules and/or peptides
* Experience with antibody and antibody fragments, bioconjugates and characterization of proteins and conjugates
* Team player with effective written and oral communication skills
* Strong publication record

Preferred Experience:

* Execution of synthetic chemistry across a wide range of chemical modalities such as small molecules, peptides, carbohydrates or nucleotides as well as payloads and linkers for conjugates
* Experience of in vitro translation/transcription and unnatural amino acid incorporation would be a plus

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we follow the science that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

Click here to request this roles pay range.

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

OFCCP EEO Supplement

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

1
Requisition ID:R106277