Bristol-Myers Squibb

Principal Scientist, Predictive Sciences

Posted on: 26 Feb 2021

Redwood City, CA

Job Description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science. In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Job Description

Seeking a collaborative and innovative scientist to join the Predictive Sciences team in the San Francisco Bay Area. This person will help advance Bristol Myers Squibbs oncology pipeline using machine learning, network analysis, and translational bioinformatics approaches on multi-omics data from internal, public, and real-world data. They will conduct analyses and help craft experiments to prioritize drug targets, enable patient selection strategies, and guide drug development decisions. Finally, this person must connect with colleagues across the organization to influence R&D from target discovery through early-stage development.

Responsibilities

* Lead computational biology efforts on multi-disciplinary teams
* Deliver results and recommendations from analysis of high-dimensional datasets (e.g., RNA-seq, WES, single-cell sequencing) to guide programs in pre-clinical drug discovery and development
* Collaborate with computational researchers, statisticians, biologists, and translational teams to develop and implement analyses that expedite our pipeline
* Develop and apply computational tools to build predictive models that can illuminate biological mechanisms of resistance to standard of care and enable patient stratification
* Communicate findings and recommend follow-up actions in multiple settings (including: 1:1, seminars, group and project meetings)

Qualifications

* PhD in bioinformatics, computational biology, computer science, engineering, statistics, genetics, or similar with 5+ years of industry experience.
* Proven track record of contributing to and helping advance multi-disciplinary team projects.
* Expertise with a high-level programming language such as R or Python for sophisticated data analysis and reproducible research practices.
* Proficiency integrating and analyzing diverse high-dimensional, omics data sets relevant for the intersection of immunology, stromal, and tumor biology.
* Capability to conduct detailed analyses to evaluate therapeutic hypotheses and prioritize clinically-relevant questions.
* Scientific curiosity with an ability to identify questions bioinformatics approaches can address, and the skills to develop solutions both independently and collaboratively.
* Excellent problem-solving skills and teamwork.
* Strong communication, data presentation, and visualization skills.
* Background in oncology/immuno-oncology and/or experience working with clinical trial or real-world data is a plus.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb

New York, New York

Bristol-Myers Squibb Company discovers, develops, licenses, manufactures, markets, distributes, and sells biopharmaceutical products worldwide. The company offers drugs in oncology, immunoscience, cardiovascular, and fibrotic diseases. The company’s products include Opdivo, a biological product for anti-cancer indications; Eliquis, an oral inhibitor targeted at stroke prevention in adult patients with non-valvular atrial fibrillation, and the prevention and treatment of venous thromboembolic disorders; and Orencia, a biological product for adult patients with moderately to severely active RA and prostate-specific antigen, as well as reducing signs and symptoms in certain pediatric patients with moderately to severely active polyarticular juvenile idiopathic arthritis.

It also provides Sprycel, a tyrosine kinase inhibitor for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia; Yervoy, a monoclonal antibody for the treatment of patients with unresectable or metastatic melanoma; Empliciti, a humanized monoclonal antibody for the treatment of multiple myeloma; and Baraclude, an oral antiviral agent for the treatment of chronic hepatitis B. In addition, the company offers Reyataz, a protease inhibitor for the treatment of human immunodeficiency virus (HIV) and Evotaz; Sustiva franchise, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV; and Daklinza NS5A replication complex inhibitor, Sunvepra NS3 protease inhibitor, and Beclabuvir NS5B inhibitor. It sells products to wholesalers, retail pharmacies, hospitals, government entities, and medical profession. It has collaboration agreements with Nektar Therapeutics; Janssen Pharmaceuticals, Inc.; Biocartis Group NV.; and FameWave Ltd.

The company was formerly known as Bristol-Myers Company and changed its name to Bristol-Myers Squibb Company in 1989. Bristol-Myers Squibb Company was founded in 1887 and is headquartered in New York, New York.

  • Industry
    Biopharmaceuticals
  • No. of Employees
    23, 300
  • Jobs Posted
    1641