Job Description

Job Description

Our Safety Assessment and Laboratory Animals Resources (SALAR) helps advance high quality drug candidates into development by defining the nonclinical safety and selectivity of lead compounds. SALAR employees evaluate Lead Optimization candidates and preclinical toxicity of drug development candidates, provide mechanistic understanding of drug-induced toxicity, and assess implications for human safety. SALAR provides collaborative research in animal model development, veterinary medical and animal care, and research facility management. Safety Assessment also responds to regulatory questions in support of drug registration.

The Investigative Toxicology (IT) Group in SALAR is looking for a Systems Toxicologist. This role will include the following primary responsibilities:

Responsibilities:

* The candidate will play a lead role in Molecular Carcinogenicity initiatives, leading efforts internally and externally. This will include the preparation of target liability assessments and Carcinogenicity Assessment Documents of drug candidates for regulatory submissions in alignment with ICH S1 guidance. This will involve diving deeply into all available data (published literature, toxicology study reports, human genomics, cancer gene databases, and target biology and pharmacologic data) to develop a weight of evidence evaluation to identify potential carcinogenicity risk.

* The candidate will also play a key role in defining and executing the overall strategy to advance several current toxicogenomic biomarkers initiatives, both diagnostic and prodromal gene expression signatures for implementation into early in vivo and in vitro derisking assays, including work in a laboratory setting.

* All of these efforts will rely heavily on strong cross-functional leadership and collaborative skills requiring the proposal, design and execution of both internal and external collaborative research in team settings.

Education Minimum Requirements:

* PhD with a minimum of 4 years of experience in an industry or academic laboratory focused on toxicology, biology, molecular biology, cancer biology, biochemistry, or related fields.

Required Experience and Skills:

* Work experience in systems toxicology and/or molecular investigative toxicology in a pharmaceutical company.

* Familiarity with molecular biology techniques, including RNA sequencing, DNA genotyping and polymorphism detection, quantitative polymerase chain reaction, and mid to high density array platforms.

* Experience in developing and qualifying gene expression signatures including those for the assessment of carcinogenicity risk.

* Familiarity with data analytics and analyses tools, such as Spotfire and/or Matlab and mathematical algorithm development and validation.

* Excellent communication (oral and written), networking, and collaboration skills.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we follow the science that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

OFCCP EEO Supplement

OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Specified

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

Number of Openings:

1
Requisition ID:R85344