Postdoctoral Fellow- Biologics Optimization: CHO Cell Engineering for Targeted Integration
Posted on: 18 Jan 2021
Thousand Oaks, CA
Job Description
The Amgen Postdoctoral Program is committed to providing future scientists with an enriched environment to encourage innovation that will contribute to the generation of human therapeutics.
We have an exciting new opening for a postdoctoral researcher in the Mammalian Expression group within Biologics Optimization at Amgen. The focus of this role is to generate novel mammalian expression systems utilizing state-of-the art genome editing and vectorology approaches. The goals are to enhance protein and vector variant library screening technologies by generating genome edited targeted integration CHO hosts and vectors; and, to improve the productivity and quality of difficult to express proteins such as bispecifics. This work may impact patients through the development of next generation biologics optimization screening approaches and novel manufacturing systems.
The successful applicant will perform independent research within the context of a highly collaborative environment and with access to state-of-the-art technologies and resources, including molecular biology, mammalian expression, protein purification and analytics, and genomics. This fellowship will provide scientific training, the opportunity to publish, and exposure to the industrial biotechnology environment at Amgen.
The assignment length is expected to be 3 years long.
Basic Qualifications
* PhD. or Doctorate degree to be completed by March 2021.
Preferred Qualifications
* PhD in Molecular Biology, Cell Biology, Genomics, or Biochemistry.
* Proven expertise and publications using current gene-editing technologies, as applied to mammalian and CHO systems.
* Experience in the generation and utilization of CHO targeted integration expression systems.
* Proficiencies in plasmid cloning, mammalian cell culturing, and genomics technologies.
* Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by high quality peer-reviewed publications.
* Research expertise in genomics data analysis.
Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.
Amgen Inc.
Oakland, CA
Amgen Inc. discovers, develops, manufactures, and delivers human therapeutics worldwide. It offers products for the treatment of oncology/hematology, cardiovascular, inflammation, bone health, and neuroscience. The company’s products include Enbrel to treat plaque psoriasis, rheumatoid arthritis, and psoriatic arthritis; Neulasta, a pegylated protein to treat cancer patients; Prolia to treat postmenopausal women with osteoporosis; Aranesp to treat anemia; Xgeva for skeletal-related events prevention; Sensipar/Mimpara products to treat sHPT in chronic kidney disease; and EPOGEN to treat a lower-than-normal number of red blood cells.
It also markets other products in various markets, including Kyprolis, Nplate, Vectibix, Repatha, NEUPOGEN, Parsabiv, Blincyto, Aimovig, Imlygic, Corlanor, Kanjintitm, and Amgevitatm. Amgen Inc. serves healthcare providers, including physicians or their clinics, dialysis centers, hospitals, and pharmacies. It distributes its products through pharmaceutical wholesale distributors, as well as direct-to-consumer channels. The company has collaborative agreements with Novartis; UCB; Bayer HealthCare Pharmaceuticals Inc.; and DaVita Inc. Amgen Inc. was founded in 1980 and is headquartered in Thousand Oaks, California.
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IndustryManufacturing
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No. of Employees21, 500
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Website
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Jobs Posted662
