Job Description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science. In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Nonclinical Research and Development (NCRD) has an opening for a Scientific Associate Director.

An experienced scientist who will work in a dynamic, multidisciplinary matrixed team within a Discovery Toxicology organization to generate, interpret and translate data from nonclinical studies. The successful candidate will be responsible for the development and execution of mechanistic investigations and biomarker strategies for programs in a wide variety of therapeutic areas. This individual will design experiments to provide a complete toxicological profile of compounds to inform advancement into early non-clinical development.

This position will require broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity. A Ph.D. in toxicology is required, and postdoctoral experience is preferred, along with evidence of a strong publication record. This is mid-career position and at least 7 years of experience in the pharmaceutical industry is desirable. Equivalent years of experience in an academic or other laboratory setting or in combination with industry experience is acceptable. Ideally, the candidate should also have demonstrable competency in directing exploratory toxicology studies and working as a toxicology project leader on discovery project teams. The candidate should possess strong skill sets related design and implementation of investigative toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic translational toxicology studies, with a particular emphasis on comparative biology. The individual should have a creative mindset and interest in developing strategies and directing innovative approaches to measure target modulation in (normal tissues) including genetic and pharmacological validation tools. A keen interest in developing in vitro systems to aid in understanding adverse effects (particularly those derived from modulation of the immune surveillance pathways) is a plus.

Responsibilities:

* Create novel experimental designs for mechanistic toxicology studies designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions

* Support predictive toxicology experimental efforts within Discovery (e.g., in vitro cell-culture based, animal models of disease) analyze safety-related data and use it to make decisions.

* As a Discovery Working Group representative, develop early safety assessment, ensure appropriate toxicology studies and liability screens are performed to support nomination of drug candidates for further development.

* Participate in issue-resolution teams, where she/he will contribute to hypotheses generation and drive the science for toxicology issue resolution in drug discovery and development.

* Communicate results clearly and concisely in both oral and written reports

* Perform in depth pathway/network analysis on data derived from toxicology and other studies and disseminate results to the wider toxicology community (internally and externally).

* Closely interact with scientists in other functional areas.

Qualifications:

* A Ph.D. in toxicology is required, and postdoctoral experience is preferred, along with evidence of a strong publication record.

* This position will require broad-based knowledge of toxicology, with emphasis on investigating molecular mechanisms of toxicity.

* This is mid-career position and at least 7 years of experience in the pharmaceutical industry is desirable.

* Equivalent years of experience in an academic or other laboratory setting or in combination with industry experience is acceptable.

* Ideally, the candidate should also have demonstrable competency in directing exploratory toxicology studies and working as a toxicology project leader on discovery project teams.

* The candidate should possess strong skill sets related design and implementation of investigative toxicology studies and use of models to support in vivo, ex vivo and in vitro mechanistic translational toxicology studies, with a particular emphasis on comparative biology.

* The individual should have a creative mindset and interest in developing strategies and directing innovative approaches to measure target modulation in (normal tissues) including genetic and pharmacological validation tools.

* Expertise in comparative immune modulation (animals and human) and a keen interest in understanding adverse effects derived from modulation of the immune surveillance pathways and understanding regulation of innate and acquired immunity in normal tissues is a plus.

* Experience with leveraging and integrating gene expression and genomics data as well as cellular approaches to identify and advance programs is desired.

* A related expertise is demonstrable capability in innovative techniques emerging from organotypic, in vitro systems and genetic modification. Experience with gene manipulation editing (RNAi, CRISPR) or image analysis is a plus.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.