Sr. Scientist - Biochemical and Quantitative Pharmacology
Posted on: 2 Jul 2021
La Jolla, CA
Job Description
Role Summary
Pfizer Oncology Research & Development (ORD) is seeking a Senior Scientist (PhD level) to join our Biochemistry and Quantitative Pharmacology (BQP) group. The candidate will join our interdisciplinary and highly collaborative team to support and advance our preclinical oncology drug pipeline. The ideal candidate will have a strong background in cellular and molecular biology, in vitro pharmacology, and biochemical and cellular assay development. Special consideration will be given to candidates that have expertise in immuno-oncology and/or cell cycle biology. The successful candidate will have a proven track record of scientific success as evidenced by publications in peer-reviewed journals. This position will provide the motivated candidate with ample opportunity for scientific growth through exposure to all aspects of the drug discovery process.
Role responsibilities
Develop and validate relevant assay systems to screen and characterize small molecules in medium and high-throughput formats.
Design, execute, analyze, and clearly communicate experimental results to drive SAR and explore novel drug targets.
Serve as BQP representative on project teams as key contributor responsible for reading current biological and technical literature and contributing new ideas to advance project work.
Contribute to a culture that prioritizes scientific discovery, pursues excellence, and encourages growth.
Basic Qualifications
PhD in the biological sciences with 2-5 years of relevant postdoctoral experience.
Demonstrated success in small molecule drug discovery with expertise in oncogenic signaling mechanisms and cellular pharmacology.
Broad knowledge of high throughput biochemical and cellular assay development including functional assays, binding assays, PPI, proliferation, degradation, and reporter assays (such as TR-FRET, NanoBRET, thermal shift, CETSA, Alpha-Screen, HiBit, flow cytometry, Mesoscale/ELISA, etc.).
Experience designing complex experiments to identify compound mechanism of action.
Attention to detail and ability to prioritize project timelines and daily activities.
Effective oral and written communication skills.
Fluency in basic data analysis software such as GraphPad, Excel, Activity Base, etc.
Preferred Qualifications
Extensive knowledge and understanding of cancer mechanisms including but not limited to immuno-oncology, DNA damage/repair, oncogenic driver signaling, epigenetics, therapeutic resistance, and apoptosis. Preference for candidates with expertise in cancer cell cycle regulation or immuno-oncology.
Experience in the design and execution of high-throughput small molecule, phenotypic, or genetic screens, including automation and large dataset analysis.
High Content screening experience is a plus.
Other Job Details
Eligible for Relocation Package
Eligible for Employee Referral Bonus
Pfizer
New York, New York
Pfizer Inc. develops, manufactures, and sells healthcare products worldwide. It offers medicines and vaccines in various therapeutic areas, including internal medicine, vaccines, oncology, inflammation and immunology, and rare diseases under the Lyrica, Chantix/Champix, Eliquis, Ibrance, Sutent, Xalkori, Inlyta, Xtandi, Enbrel, Xeljanz, Eucrisa, BeneFix, Genotropin, and Refacto AF/Xyntha brands. The company also provides consumer healthcare products that comprise over-the-counter medicines, including dietary supplement products under the Centrum, Caltrate, and Emergen-C names; pain management products under the Advil and ThermaCare names; gastrointestinal products under the Nexium 24HR/Nexium Control and Preparation H names; and respiratory and personal care products under the Robitussin, Advil Cold & Sinus, and ChapStick names. In addition, it offers products that would lose or have lost marketing patent protection; branded generic products; generic sterile injectable products; biosimilars; and anti-infectives under the Lipitor, Premarin family, Norvasc, Lyrica, Celebrex, Viagra, Inflectra/Remsima, Zyvox, Vfend, Revatio, Inspra, Medrol, Sulperazon, Fragmin, Tygacil, Nivestim, and Retacrit, Ixifi Infliximab BS names.
Further, the company is also involved in the contract manufacturing business. It serves wholesalers, retailers, hospitals, clinics, government agencies, pharmacies, and individual provider offices, as well as disease control and prevention centers. The company has collaboration and/or co-promotion agreements with Bristol-Myers Squibb Company, Astellas Pharma US, Inc., and Oncolytics Biotech Inc.; licensing agreement with BionTech AG; strategic alliance with Verily Life Sciences LLC; and collaboration agreements with Pfizer, Merck & Co., Inc., and Eli Lilly & Company, as well as with Merck KGaA and Nektar Therapeutics to develop a therapy for treating pancreatic cancer. Pfizer Inc. was founded in 1849 and is headquartered in New York, New York.
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IndustryBiopharmaceuticals
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No. of Employees92,400
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Website
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Jobs Posted2412
