Job Description

Job Description

Our Research Division in South San Francisco, a wholly owned subsidiary of our company is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with our company's world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay areas biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of our company's powerful world-class network of therapeutic discovery across multiple modalities that include small molecules and biologics.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Research Division labs in South San Francisco, youll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) department of our Research Division at South San Francisco is seeking a dynamic, strategic-thinking, and collaborative scientist for the Absorption, Distribution, Metabolism and Excretion (ADME) group. The Associate Principal Scientist will partly be discovery team-facing and be expected to visibly be a key contributor to the multi-disciplinary drug discovery effort for various therapeutics (small molecule, antibody-drug conjugate, peptide, and biologic therapeutics) that are most likely to succeed clinically. The candidate will need to regularly engage with partner functions like medicinal and computational chemistry, translational pharmacology, pharmaceutics, and toxicology. Therapeutic areas will include immunology, oncology, cardiovascular and metabolic disease, and ophthalmology. The Associate Principal Scientist will partly be lab-facing either as an experimentalist themselves or by partnering with other experimentalists to drive laboratory research particularly around biochemistry and enzymology.

The responsibilities of the Associate Principal Scientist will be to work collaboratively in a fast-paced environment to contribute to the prediction, design, implementation, and analysis of in silico, in vitro, and in vivo studies. Those studies will characterize and build an understanding of key structure-activity relationships (SAR) related to ADME and pharmacological properties, therapeutic disposition, and translational pharmacokinetic-pharmacodynamic/efficacy (tPKPD/E) relationships. The candidate will be able to leverage the understanding of molecular characteristics impacting disposition and tPKPD/E relationships to guide both drug design and implementation of strategy(ies) for the translation of preclinical results to anticipated clinical efficacy. Excellent scientific, interpersonal, and communication skills are required. The candidate will be expected to effectively present their work at discovery team and departmental meetings as well as promote our company's science through publications and presentations/lectures.

Education:

* Required Education: PhD, MS, or BS degrees in Pharmaceutical Sciences, Chemistry, Biochemistry, Immunology, Pharmacology, Engineering, or related science.

Required Experience and Skills:

* PhD (+4 years), MS (+8 years), BS (+12 years) of combined industry and/or postdoctoral (or fellowship) experience focused on providing ADME and PK support for optimization of small molecule therapeutics.

* Technical understanding of ADME assays and their interpretation.

* Contributed to development, execution, and fostering of translational pharmacokinetic-pharmacodynamic/efficacy (tPKPD/E) relationships and other useful quantitative pharmacology applications in a discovery setting.

* Strong leadership, interpersonal, communication, problem solving, and collaboration skills along with strengths in delivering results in fast-pace environment.

Preferred Experience:

* Experience with mass spectrometry-based profiling and characterization.

* Strategically used structure-activity relationships (SAR) related to ADME and pharmacological properties to drive optimization of therapeutics.

* Hands-on experience in computational ADME predictions and visualizations.

* Demonstrated inclination towards recognition in the field, creativity and innovation via a strong publication/presentation record.

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we follow the science that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Specified

Shift:

Not Indicated

Valid Driving License:

Yes

Hazardous Material(s):

Number of Openings:

1
Requisition ID:R111477