Job Description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science. In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Job Description

The Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics (QSP & PBPK) function within Clinical Pharmacology & Pharmacometrics (CP&P) is searching for a new scientist, preferably with expertise in cardiovascular applications of QSP. The individual will:

* Develop and apply QSP models to address drug-discovery and clinical development questions
* As needed, work with external groups to accelerate the internal QSP efforts
* Provide expert support to project teams to design, execute and interpret clinical studies with supervision
* Leverage existing virtual population workflows and script-based analysis packages with supervision
* With some supervision, network with stakeholders to facilitate model development and application
* With some supervision, align QSP model deliverables with the clinical pharmacology and clinical development plans
* Stay informed with emerging literature and science in the systems biology/pharmacology modeling and simulation sciences
* Build and maintain a personal track record of publication in the area of QSP

Position Requirements

* Ph.D. in Engineering, Mathematics, Bioinformatics, Pharmacometrics, Systems Biology/Pharmacology or a related field. M.S. in appropriate field with significantly more experience may be considered
* 2+ years of mathematical modeling & computer simulation experience for biomedical/pharmaceutical applications. Experience within pharmaceutical industry or pharmaceutical consulting is desired (post-doctoral or academic experience could be considered depending on the totality of prior experience)
* Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation.
* Knowledge of process control theory would be beneficial
* Good understanding of the basic principles of pharmacokinetics and pharmacodynamics
* Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop QSP models
* Ability to communicate internally and externally on topics related to CP&P and QSP is required
* Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology
* Hands-on experience with modeling software like MATLAB/Simulink/SimBiology, JDesigner/Systems Biology Workbench, Entelos PhysioLab Platform, DBSolve, etc.
* Experience with general programming and data analysis tools/languages such as Python, R, MATLAB, Spotfire, etc., is required
* Desire to interact as a modeling and simulation expert across clinical development teams with experts from different functional areas (pre-clinical and clinical)
* Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as clinical pharmacology, bioanalytical, biopharmaceutics, and toxicology
* Knowledge of human physiology, cardiology, renal physiology is a plus

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.