Pfizer

Sr. Principal Scientist - Cell Biology, Oncology Drug Discovery

Posted on: 15 Mar 2021

Boulder, CO

Job Description

ROLE SUMMARY

Array BioPharma (recently acquired by Pfizer) is a biopharmaceutical company headquartered in Boulder, CO with locations in Cambridge, MA and Morrisville, NC. We are focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array recently received approval and launched BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.

With more than 300 days a year of sunshine, Boulder is a paradise in the West! Hikers, bikers, foodies, beer enthusiasts, art and theater lovers, and more feel right at home here. Visit https://www.bouldercoloradousa.com/ to discover what we love about Boulder. Many Array colleagues live just outside of Boulder in Longmont, Westminster, Lafayette, and other surrounding communities and have commutes of only 15 to 20 minutes.

The individual will contribute to preclinical drug discovery programs from target selection candidate identification and characterization. They will leverage their expertise in oncology cell biology to identify new targets that align with the site strategy, develop assays to support drug discovery programs, guide programs, and oversee the design and execution of compound mechanism-of-action studies.

ROLE RESPONSIBILITIES

* Identifies strategic and tactical challenges for each of the drug discovery programs that they support, and identify experiments to address these challenges

* Design and oversee studies to characterize the biological consequences of a given mechanism of action to enable generation of a robust clinical development plan to identify relevant cancer types, target patient population, potential combination strategies and mechanisms of resistance

* Directly supervise and mentor 2-3 scientists supporting multiple discovery programs

* Maintain state-of-the-art technical knowledge

* Monitor all relevant literature with respect to potential and current targets

* Contribute to written and oral presentations

BASIC QUALIFICATIONS

* PhD with at least 8 years industry experience with a focus in Oncology.

* Strong familiarity with small molecule drug discovery from lead identification to candidate nomination

* Significant experience supervising, mentoring and developing the careers of scientists of all experience levels

* Strong leader who understands their roles and responsibilities and works to empower their direct reports and project team members to contribute to the overall success of the efforts they support

* Highly refined oral and written communication skills with the ability to effectively articulate key concepts to all levels of the organization as well as externally

* Ability to work in a fast-paced environment with a high degree of independence to effectively address both strategic and tactical challenges, leveraging their solid understanding of cell biology and oncology

* Recognized company-wide as a subject matter and/or technical expert in one or more areas

* Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

PREFERRED QUALIFICATIONS

* PhD in Biology

OTHER JOB DETAILS

* Eligible for Relocation Package

* Eligible for Employee Referral Bonus

* LI-PFE

The annual base salary for this position ranges from $106,300 to $177,100. In addition, this position offers an annual bonus with a target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

LI-PFE

Pfizer

New York, New York

Pfizer Inc. develops, manufactures, and sells healthcare products worldwide. It offers medicines and vaccines in various therapeutic areas, including internal medicine, vaccines, oncology, inflammation and immunology, and rare diseases under the Lyrica, Chantix/Champix, Eliquis, Ibrance, Sutent, Xalkori, Inlyta, Xtandi, Enbrel, Xeljanz, Eucrisa, BeneFix, Genotropin, and Refacto AF/Xyntha brands. The company also provides consumer healthcare products that comprise over-the-counter medicines, including dietary supplement products under the Centrum, Caltrate, and Emergen-C names; pain management products under the Advil and ThermaCare names; gastrointestinal products under the Nexium 24HR/Nexium Control and Preparation H names; and respiratory and personal care products under the Robitussin, Advil Cold & Sinus, and ChapStick names. In addition, it offers products that would lose or have lost marketing patent protection; branded generic products; generic sterile injectable products; biosimilars; and anti-infectives under the Lipitor, Premarin family, Norvasc, Lyrica, Celebrex, Viagra, Inflectra/Remsima, Zyvox, Vfend, Revatio, Inspra, Medrol, Sulperazon, Fragmin, Tygacil, Nivestim, and Retacrit, Ixifi Infliximab BS names.

Further, the company is also involved in the contract manufacturing business. It serves wholesalers, retailers, hospitals, clinics, government agencies, pharmacies, and individual provider offices, as well as disease control and prevention centers. The company has collaboration and/or co-promotion agreements with Bristol-Myers Squibb Company, Astellas Pharma US, Inc., and Oncolytics Biotech Inc.; licensing agreement with BionTech AG; strategic alliance with Verily Life Sciences LLC; and collaboration agreements with Pfizer, Merck & Co., Inc., and Eli Lilly & Company, as well as with Merck KGaA and Nektar Therapeutics to develop a therapy for treating pancreatic cancer. Pfizer Inc. was founded in 1849 and is headquartered in New York, New York.

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