Co-op: Native Mass Spectrometry
Posted on: 15 Mar 2021
Cambridge, MA
Job Description
Job Description
This is for a 6-month position from July - December 2021.
The Analytical Biochemistry Group is a part of the Biotherapeutics and Medicinal Sciences Department within Research and Development. We provide biochemical and biophysical data for protein drug candidates and for protein reagents used for early discovery, transition, and development projects. This work helps to advance Biogens goal of bringing new therapies for patients with unmet medical needs. Our work includes characterization of protein structures by intact mass analysis, peptide mapping, disulfide linkage analysis, carbohydrate analysis, and hydrogen deuterium exchange using various LC-MS systems.
Position Description
The co-op position will involve study of non-covalent protein-protein, protein-ligand complexes and viral capsid load determination by native mass spectrometry using a Thermos Q Exactive UHMR mass spectrometer. Work will include preparation of samples, operation of the mass spectrometer coupled with a nanospray ion source, optimization and development of methods, and analysis of data. The results will provide valuable insights into biomolecular complexes structure and interaction, including stoichiometry, reversibility, site-specificity, affinity and polar contributions to the binding.
Qualifications
To participate in the Biogen Co-op Program, students must meet the following eligibility criteria:
* Legal authorization to work in the U.S.
* Grade point average of 3.2 or higher preferred
* At least 18 years of age prior to the scheduled start date
* Be currently enrolled in an accredited college or university
Additional qualifications:
* Enthusiastic, passionate about science, and self-motivated.
* Knowledge of protein mass spectrometry and lab experience in mass spectrometry.
* Experience in native mass spectrometry is required.
Education
Undergraduate or graduate student (preferred) in analytical chemistry, biochemistry or related fields.
Additional Information
All your information will be kept confidential according to EEO guidelines.
Biogen
Cambridge, MA
Biogen Inc. discovers, develops, manufactures, and delivers therapies for treating neurological and neurodegenerative diseases worldwide. The company offers TECFIDERA, AVONEX, PLEGRIDY, TYSABRI, and FAMPYRA for the treatment of multiple sclerosis (MS); SPINRAZA for the treatment of spinal muscular atrophy; and FUMADERM for the treatment of plaque psoriasis. It also provides BENEPALI, an etanercept biosimilar referencing ENBREL; FLIXABI, an infliximab biosimilar referencing REMICADE; and IMRALDI, an adalimumab biosimilar referencing HUMIRA. In addition, the company offers RITUXAN for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), rheumatoid arthritis, two forms of ANCA-associated vasculitis, and pemphigus vulgaris; RITUXAN HYCELA for non-Hodgkin's lymphoma and CLL; GAZYVA to treat CLL and follicular lymphoma; and OCREVUS for the treatment of primary progressive MS and relapsing MS, and other anti-CD20 therapies.
Further, it is involved in developing BIIB098, Opicinumab, and BIIB061 for MS and neuroimmunology; Aducanumab, Elenbecestat, BAN2401, BIIB092, BIIB076, and BIIB080 to treat Alzheimer's disease and dementia; BIIB092 and BIIB054 for treating Parkinson's disease and movement disorders; BIIB067, BIIB078, and BIIB110 to treat neuromuscular disorders; BIIB093, TMS-007, and Natalizumab to treat acute neurology; BIIB104 for treating neurocognitive disorders; BIIB074 and BIIB095 for pain; and Dapirolzumab pegol, BG00011, and BIIB059 for treating other diseases, which are under various stages of development.
The company offers products through its sales force and marketing groups. Biogen Inc. has collaboration agreements with Genentech, Inc., Eisai Co., Ltd., Alkermes Pharma Ireland Limited, Bristol-Myers Squibb Company, Acorda Therapeutics, Inc., AbbVie Inc., C4 Therapeutics, University of Pennsylvania, Applied Genetic Technologies Corporation, and others. The company was founded in 1978 and is headquartered in Cambridge, Massachusetts.
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IndustryBiotechnology
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No. of Employees7,800
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Website
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Jobs Posted445
