Bristol-Myers Squibb

Manager, MS&T Downstream

Posted on: 5 Mar 2021

Devens, MA

Job Description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science. In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Engineer/Scientist Downstream in Manufacturing Sciences & Technology supports the commercial manufacturing of biopharmaceuticals in the area of purification and primary recovery. The successful candidate will be a key contributor and subject matter expert to a highly technical, diverse, and collaborative team of scientists and engineers. MS&T scientists and engineers contribute to cross-functional teams to meet highly visible business objectives. The position offers the opportunity to interface with Manufacturing, Manufacturing Support, Process Development, Quality Assurance, Analytical, and Global Regulatory Sciences groups.

Responsibilities include but are not limited to:

* Supporting commercial manufacturing process by providing technical expertise for investigation of downstream process deviations, root cause analysis, CAPAs, and process improvements. Supporting process technology transfer, process validation and CMC documentation preparation.
* Following GLP/GMP procedures to design and execute protocols to solve process-related manufacturing investigations and enabling the technology transfer of new processes to larger scale manufacturing through the use of laboratory and pilot scale-down models in protein chromatography, viral inactivation, viral filtration, ultrafiltration/diafiltration, membrane filtration, depth filtration, and centrifugation.
* Documentation of experimental data and results, data verification, interpretation of data with respect to the laboratory protocol and the manufacturing process, and preparation of final reports to summarize the findings.
* Effective collaborations with Manufacturing, Manufacturing Support, Process Development, Quality Assurance, Analytical and Global Regulatory Sciences groups. Strong communication and technical writing skills are required.
* Evaluation of new process technologies.

Qualifications:

* BS or MS or PhD in Chemical/Biochemical Engineering or Biochemistry related field. BS or equivalent with a minimum 5 years relevant industrial experience, MS or equivalent with minimum of 4 years relevant industrial experience, Ph.D. with 0-4 years of relevant experience.
* Solid scientific understanding of protein purification and protein stability is required. Lab experience with AKTA purification and ultrafiltration/diafiltration operations is preferred.
* Critical qualities include a high level of scientific curiosity and critical thinking ability, good verbal/written communication skills to interface with multi-disciplinary teams.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Bristol-Myers Squibb

New York, New York

Bristol-Myers Squibb Company discovers, develops, licenses, manufactures, markets, distributes, and sells biopharmaceutical products worldwide. The company offers drugs in oncology, immunoscience, cardiovascular, and fibrotic diseases. The company’s products include Opdivo, a biological product for anti-cancer indications; Eliquis, an oral inhibitor targeted at stroke prevention in adult patients with non-valvular atrial fibrillation, and the prevention and treatment of venous thromboembolic disorders; and Orencia, a biological product for adult patients with moderately to severely active RA and prostate-specific antigen, as well as reducing signs and symptoms in certain pediatric patients with moderately to severely active polyarticular juvenile idiopathic arthritis.

It also provides Sprycel, a tyrosine kinase inhibitor for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia; Yervoy, a monoclonal antibody for the treatment of patients with unresectable or metastatic melanoma; Empliciti, a humanized monoclonal antibody for the treatment of multiple myeloma; and Baraclude, an oral antiviral agent for the treatment of chronic hepatitis B. In addition, the company offers Reyataz, a protease inhibitor for the treatment of human immunodeficiency virus (HIV) and Evotaz; Sustiva franchise, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV; and Daklinza NS5A replication complex inhibitor, Sunvepra NS3 protease inhibitor, and Beclabuvir NS5B inhibitor. It sells products to wholesalers, retail pharmacies, hospitals, government entities, and medical profession. It has collaboration agreements with Nektar Therapeutics; Janssen Pharmaceuticals, Inc.; Biocartis Group NV.; and FameWave Ltd.

The company was formerly known as Bristol-Myers Company and changed its name to Bristol-Myers Squibb Company in 1989. Bristol-Myers Squibb Company was founded in 1887 and is headquartered in New York, New York.

  • Industry
    Biopharmaceuticals
  • No. of Employees
    23, 300
  • Jobs Posted
    1641

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