Job Description

Why Patients Need You

Pfizers purpose is to deliver breakthroughs that change patients lives. Research and Development is at the heart of fulfilling Pfizers purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

Description

Pfizer Oncology Research & Development (ORD) is seeking a Senior Scientist (PhD level) to join our Biochemistry and Quantitative Pharmacology group. The candidate will join our interdisciplinary and highly collaborative team to support and advance our preclinical oncology drug pipeline. The ideal candidate will have a strong background in cell and molecular biology, in vitro pharmacology, and biochemical/cell assay development. They will design, plan, and execute studies to explore novel drug targets. They will implement new technologies to support drug discovery, interpret experimental results, and present their research. The successful candidate will have a proven track record of scientific success as evidenced by publications in peer-reviewed journals. This position will provide the motivated candidate with ample opportunity for scientific growth through exposure to all aspects of the drug discovery process. Special consideration will be given for candidates that have expertise in cell cycle biology.

Role responsibilities:

* In-depth knowledge of oncogenic signaling mechanisms is used to bring novel approaches to biochemical and cell pharmacology.

* Innovative technologies are used to find creative ways to support drug discovery.

* Develop and validate relevant assay systems to screen and characterize small molecules in medium and high-throughput formats.

* Design, execute, analyze, and interpret experiments to drive SAR

* Results and methodologies will be clearly communicated to teams and appropriately documented in laboratory notebooks.

* Keep current with appropriate biology and technical literature, and contribute new ideas to advance project work.

* Contribute to a culture that prioritizes scientific discovery, pursues excellence, and encourages growth.

Basic Qualifications:

* A PhD in the biological sciences with 2-5 years of relevant postdoctoral experience.

* Expertise in oncogenic signaling pathways, molecular biology, and biochemistry.

* Has demonstrated success in biochemical and cellular assay design and development such as thermo-shift, CETSA, Alpha-Screen, HTRF, qPCR, Nanoluciferase/HiBit, flow cytometry, Mesoscale/ELISA, etc.

* Experience designing complex experiments to identify compound mechanism of action.

* Has demonstrated innovation through the implementation of new assays.

* Attention to detail, and ability to multi-task/ prioritize and time management of daily activities.

* Demonstrates effective oral and written communication skills.

* Fluency in basic data analysis software such as GraphPad, Excel, Activity Base, etc.

Preferred Qualifications:

* Extensive knowledge and understanding of cancer mechanisms including but not limited to oncogenic driver signaling, epigenetics, immuno-oncology, DNA damage/repair, therapeutic resistance, and apoptosis.

* Preference for candidates with expertise in cancer cell cycle regulation or DNA damage/repair.

* Strong molecular biology skillset including genetic approaches to validate target biology such as CRISPR-Cas9 or si/shRNA.

* Experience in the design and execution of high-throughput small molecule or genetic screens, including automation and large dataset analysis.

* High Content screening experience is a plus.

PHYSICAL/MENTAL REQUIREMENTS

* Basic job will require both work at the lab bench and analysis time at the computer.

Other Job Details:

* Last Date to Apply for Job:
* Eligible for Relocation Package: YES
* Eligible for Employee Referral Bonus: YES

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

LI-PFE