Job Description

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough.

We are seeking a highly motivated Associate Principal Scientist to join our Biologics Analytical Research & Development at our Company's Research & Development Division in Kenilworth, NJ. The qualified candidate will be responsible for analysis and characterization of host-cell proteins (HCP) using immunoassays and orthogonal methods to support early/late-stage development of biologics and vaccines pipeline; other responsibilities include development of custom HCP reagents, assay development/ qualification/ transfer, and benchmarking current approaches/ techniques to the industry standards. The candidate will be expected to communicate results effectively in presentations to stakeholders in partner organizations or at external scientific meetings, to write technical reports, and to participate in cross-functional teams.

Education Minimum Requirements:

* B.S. degree in microbiology, biochemistry, cell biology, biological sciences or engineering, with 10 years of experience: Ph.D. degree with 4+ years or M.S. degree with 8+ years of professional drug development experience in the pharmaceutical industry.

Required Experience and Skills:

* Knowledge of host-cell protein impurity analysis for biologics and vaccines including reagent generation and coverage assessment.

* Expertise in ELISA-based immunochemistry principles applied to various technology platforms (Meso Scale Discovery, EnVision, ForteBio, Gyros, etc.).

* Knowledge of protein chemistry including bio-conjugation and experience with protein analysis and purification skills such as SDS-PAGE gels, Western blots, SEC-HPLC, and affinity purification.

* Knowledge of two-dimensional electrophoresis (2D-E), 2D-difference in gel electrophoresis (2D-DIGE), and 2D differential in blot electrophoresis (2D-DIBE) for protein profile analysis.

* A strong team player with excellent oral and written communication skills; ability to work independently to develop and design experiments, critically evaluate data, and troubleshoot.

* Strong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment.

Preferred Experience and Skills:

* Knowledge of proteomics and skills for comparison with 2D-E analysis.

* Experience in liquid handling system and automation.

* Proficiency to utilize statistical software for design of experiments.

* Excellent scientific publishing records.

* Working knowledge of regulatory and industry guidelines in the area of in-process residual testing.

* Experience in assay evaluation (range, linearity, precision, accuracy, and LOQ, etc.) and qualification in accordance with ICH guidelines.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we follow the science that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

ARandD

Who we are

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the worlds biggest investors in Research & Development.

What we look for

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at staffingaadar@msd.com
For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement

OFCCP EEO Supplement

OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Specified

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

Number of Openings:

1
Requisition ID:R79774