Sr. Scientist - Structural Biology
Posted on: 23 Jan 2021
South San Francisco, CA
Job Description
Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions.
The Amgen research laboratory provides comprehensive molecular insight and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across various important therapeutic areas. The Scientist will be part of a growing structure biology group and will be responsible for designing and purifying target proteins for Cryo-Electron Microscopy and X-ray crystallography, data collection and resolution of complex molecular structures.
Preferred qualifications and major accountabilities associated with this role include:
* Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, crystallization, structure determination and analysis.
* Experience in single particle cryo-EM processes (including sample/grid preparation and screening, data collection and processing, three-dimensional reconstruction and model building)
* Familiarity with Linux OS (install, configure and maintain) is a strong plus.
* Excellent presentation skills (written and oral) that enhance team-based delivery of results
* Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment
* Skills in managing multiple projects and capability to prioritize
* The ideal candidates should have Ph.D in structural biology with significant postdoc research experience in membrane proteins and/or large macromolecular complexes
Amgen Inc.
Oakland, CA
Amgen Inc. discovers, develops, manufactures, and delivers human therapeutics worldwide. It offers products for the treatment of oncology/hematology, cardiovascular, inflammation, bone health, and neuroscience. The company’s products include Enbrel to treat plaque psoriasis, rheumatoid arthritis, and psoriatic arthritis; Neulasta, a pegylated protein to treat cancer patients; Prolia to treat postmenopausal women with osteoporosis; Aranesp to treat anemia; Xgeva for skeletal-related events prevention; Sensipar/Mimpara products to treat sHPT in chronic kidney disease; and EPOGEN to treat a lower-than-normal number of red blood cells.
It also markets other products in various markets, including Kyprolis, Nplate, Vectibix, Repatha, NEUPOGEN, Parsabiv, Blincyto, Aimovig, Imlygic, Corlanor, Kanjintitm, and Amgevitatm. Amgen Inc. serves healthcare providers, including physicians or their clinics, dialysis centers, hospitals, and pharmacies. It distributes its products through pharmaceutical wholesale distributors, as well as direct-to-consumer channels. The company has collaborative agreements with Novartis; UCB; Bayer HealthCare Pharmaceuticals Inc.; and DaVita Inc. Amgen Inc. was founded in 1980 and is headquartered in Thousand Oaks, California.
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IndustryManufacturing
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No. of Employees21, 500
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Website
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Jobs Posted662
