Job Description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science. In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attack neurological diseases. Internal research focuses on protein homeostasis by direct and ligand directed degradation, neuroinflammation and remyelination.

Areas of interest include, but are not limited to, the following approaches:

Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Emerging technologies (RNA, DNA targeting, gene regulation, editing and replacement, vector optimization) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in orphan/rare neurological and neuromuscular diseases. AI/ML in target identification and neurology drug discovery; Translational tools and technologies such as neuroimaging and fluid biomarkers to track neurodegenerative disease; Novel blood brain-barrier delivery technologies.

Position Summary:

The Principal Scientist is a laboratory-based, integral member of the Neuroscience TRC with a focus on research project and clinical stage asset support for neurodegenerative indications. The successful applicant will leverage their experience in inflammation/immunology and in vitro/ex vivo expertise, working collaboratively with other team members across disciplines to pharmacologically characterize target engagement in CNS-relevant models using ex vivo tissues or iPSCs/coculture systems. This position offers great potential for continued growth with exposure to all aspects of disease modelling and drug development and as such, in vivo experience would be considered highly advantageous. The Principal Scientist will also be in a position to offer training and oversight to junior team members while participating in project teams and contributing to regulatory submissions.

Responsibilities:

* Implementation and validation of assay systems in relevant cell types to screen and characterize the pharmacological responses to modulation with small molecules, antibodies etc.

* Development of assays with readouts that are relevant to the primary neurodegeneration indications

* Identification and assessment of potential new Neuroscience-focused targets

* Generate, record and report raw data and interpret to refine the next steps

* Ensure the proper documentation of all data in electronic notebooks

* Analysis and presentation of data in Excel and GraphPad Prism, as appropriate and including statistical analysis

* Presentation of data updates at project team and departmental meetings

* Ability to participate in and oversee outsourced projects/collaborations

* Creation and interpretation of scientific documents including study protocols and study reports suitable for regulatory submission

* Mentorship of junior team members

* Other responsibilities as assigned

Requirements:

* Ph.D. in Biology (or similar field) and 3+ years of relevant work experience (neuroscience or neuroimmunology)

* Supervisory experience is considered advantageous

* Demonstrated history of using in vitro/ex vivo laboratory skills applied to drive progress in varied projects

* Data interpretation and application to the design of follow-on studies

* Skilled in using standard software as well as specialist equipment, graphing and statistical analysis software

* Capable of working within a fast-paced team environment contributing to multiple projects at any given time

* Ability to work independently but collaboratively within a solid team environment

* Good organizational, record keeping, plus oral and written communication skills

* Motivated and detail-oriented with a strong interest in driving productivity in clinically-directed research

* Positively contribute to a work environment that fosters professionalism, mutual respect, teamwork, output and collaboration

BMSNEURO

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.